Matilla de los Caños del Río is a village and municipality in the province of Salamanca, western Spain, part of the autonomous community of Castile-Leon. It is located 34 kilometres from the provincial capital city of Salamanca and has a population of only 705 people.
The municipality covers an area of 69.29 km².
It lies 818 metres above sea level.
The post code is 37450.